I don’t know about you but I would never expect to see body modification, body horror, or genetic experimentation in a ninja themed manga. It’s all in Masahi Kishimoto’s Naruto.
Disclaimer: THE CONTENT BELOW IS FILLED WITH SPOILERS! PROCEED AT YOUR OWN PERIL!
Madara Uchiha implanted his rival, Hashirama Senju’s DNA into his body and gained his botanical manipulation ninjutsu. A strange growth that resembled Hashirama appeared on his chest as a result.
Obito, descendant of the legendary Uchiha clan, was grievously injured in combat and would have perished without Madara’s intervention. Madara replaced damaged limbs with White Zetsu parts (a White Zetsu is essentially an artificial plant being derived from Hashirama Senju and possessing botanical manipulation and shape shifting abilities). Obito could sprout thorns and grow trees from his Zetsu parts.
Nagato, a descendant of the Uzumaki clan and recipient of Madara’s Rinnegans (a Rinnegan is an ocular mutation possessed by the creator of ninjutsu, the Sage of the Six Path). He was able to manifest black rods on his back which enabled him to animate cadavers, replicate the Rinnegan within them, and utilize the Sage ninjutsu through them. He is able to “operate” 6 proxies remotely, see through their eyes, and coordinate attacks.
Kabuto, the medical ninja and faithful apprentice of Orochimaru, build upon the genetic research of his master & experimented on himself. He integrated his master’s true form (Orochimaru’s true form is serpentine and composed of a mass of white snakes as a result of his experimentation) into himself and the genetic material of Orochimaru’s elite minions. Kabuto’s skin became scaly and white, his eyes became serpentine and he gained a body similar to a naga (with a chimera tail). When he entered Sage Mode, he regained humanoid legs, grew horns, and the “chimera tail” moved to his belly button. His “tail” could replicate the forms of the genetic donors & manifest their unique abilities.
Shin Uchiha is a former test subject and experiment of Orochimaru. His unique body accepted all transplanted organs and genetic material. He was cloned in order to discover the secret of his unique physiology. He possesses a transplanted Sharingan eye in his right eye socket (a Sharingan is an ocular mutation unique to the Uchiha clan and consumes a massive amount of energy when transplanted in and used by non-Uchiha). He has numerous Sharingans all over his body. He can teleport with his fully evolved eye and control objects he marked telekinetically. He can see through a proxy Sharingan creature and utilize the teleportation ability.
Original Art by Masashi Kishimoto and the animation cells are by Studio Pierrot